Lithium Hydroxide → HCID 67304728, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 8, N-(5-ethylisoxazol-3-yl)-2-[4-(7-methoxy-6-methoxycarbonylquinolin-4-yloxy)phenyl]acetamide was reacted with lithium hydroxide to give the title compound in 78% yield; 1H NMR: (DMSOd6) 1.2 (t, 3H), 2.68-2.78 (m, 2H), 3.76 (s, 2H), 3.99 (s, 3H), 6.5 (d, 1H), 6.64 (s, 1H), 7.29 (d, 2H), 7.47 (d, 2H), 7.51 (s, 1H), 8.56 (s, 1H), 8.68 (d, 1H), 11.22 (br s, 1H); Mass Spectrum: M+H+ 448.

Provenance & Evidence