HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromobutanoic acid → HCID 58033009, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromobutanoic acid | HCID 6655 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-(2-Chloro-benzyl)-thiazol-2-ylamine | HCID 727745 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 58033009 | HCID 58033009 | — |
Reaction Steps
5-(2-Chloro-benzyl)-thiazol-2-ylamine (0.484 g, 2.16 mmol) and 2-bromo-butyric acid (0.360 g, 2.16 mmol) were dissolved in acetonitrile (20 mL) containing triethylamine (302 μL, 2.16 mmol). O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (1.15 g, 3.02 mmol) was added and the solution was allowed to stir for 16 hours. The crude product was purified by silica gel chromatography. ESI-MS m/z calc. 372.0, found 373.2 (M+1)+ Retention time 3.41 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07973169B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-e7f44c5308a14134bac4984cd5838e94 |
| Source note | uspto-grants-2011_07 |