HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 58033085, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | alpha-Cyclohexylphenylacetic acid | HCID 97942 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 58033070 | HCID 58033070 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58033085 | HCID 58033085 | — |
Reaction Steps
5-(4-Chloro-benzyl)-oxazol-2-ylamine (42 mg, 0.20 mmol) and cyclohexyl-phenyl-acetic acid (44 mg, 0.20 mmol) were dissolved in N,N-dimethylformamide (1 mL) containing triethylamine (84.1 μL, 0.600 mmol). O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (84 mg, 0.22 mmol) was added and the solution was allowed to stir for 16 hours. The crude product was purified by reverse-phase preparative liquid chromatography (9.6 mg, 0.023 mmol, 12%). ESI-MS m/z calc. 408.9, found 409.4 (M+1)+ Retention time 3.76 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07973169B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-3348a449eba64714831b86e316c84e73 |
| Source note | uspto-grants-2011_07 |