Lithium hydroxide, monohydrate → HCID 57659364, compound

Participants

Reaction Steps

A solution of (3aR,9bS)-1-((S)-2-hydroxy-1-phenylethyl)-1,3a,4,9b-tetrahydrospiro[benzo[g]indole-5,4′-piperidin]-2(3H)-one (Step 4, 2.3 g, 6.1 mmol) and lithium hydroxide monohydrate (2.3 g, 55 mmol) in DMSO (15 ml) was heated at 170° C. for 4 h. The reaction mixture was evaporated. The residue was poured into water, extracted with EtOAc (3×). The extracts were concentrated to give the title compound as brown oil (1.5 g).

Provenance & Evidence