HCID 86638445, compound → HCID 24853446, compound

Participants

Reaction Steps

To a methanol solution (1 mL) of (1S)-1,5-anhydro-2,3,4,6-tetra-O-benzyl-1-[2-(benzyloxy)-5-[4-[(1E)-4-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]-4-oxobut-1-en-1-yl]benzyl]-4-methylphenyl]-D-glucitol (91 mg, 0.0926 mmol) was added 10% palladium-activated carbon (16 mg), and the mixture was stirred overnight under a hydrogen atmosphere at room temperature. The reaction solution was filtered through celite, and evaporated under reduced pressure to obtain a residue. Thus obtained residue was dissolved in methanol (1 mL). And 20% palladium hydroxide (91 mg) was added thereto, and the mixture was stirred under hydrogen atmosphere at room temperature for 2 days. The reaction solution was filtered through celite, and evaporated under reduced pressure to obtain a residue. Thus obtained residue was purified with silica gel column chromatography (chloroform:methanol=5:1) to obtain the title compound (32 mg, 65%) as a colorless powder. NMR data and MS data of the compound are shown in Table 1.

Provenance & Evidence