HCID 86638446, compound → HCID 24851758, compound

Participants

Reaction Steps

To a methanol solution (1 mL) of (1S)-1-[5-(4-[(1E)-4-[(2-amino-1,1-dimethyl-2-oxoethyl)amino]-4-oxobut-1-en-1-yl]benzyl)-2-(benzyloxy)-4-methylphenyl]-1,5-anhydro-2,3,4,6-tetra-O-benzyl-D-glucitol (75 mg, 0.0765 mmol) was added 20% palladium hydroxide (15 mg), and the mixture was stirred overnight under a hydrogen atmosphere at room temperature. The reaction solution was filtered through celite, and evaporated under reduced pressure to obtain a residue. Thus obtained residue was purified with silica gel column chromatography (chloroform:methanol=5:1, ethyl acetate:ethanol:water=20:2:1) to obtain the title compound (32 mg, 79%) as a colorless powder. NMR data and MS data of the compound are shown in Table 1.

Provenance & Evidence