Carbon Dioxide → HCID 24851762, compound

Participants

Reaction Steps

To a methanol solution (1 mL) of (1S)-1-[2-(acetoxy)-5-[4-[3-[[[[2-(acetoxy)-1,1-dimethylethyl)amino]carbonyl]amino]propyl]benzyl]-4-methylphenyl]-1,5-anhydro-2,3,4,6-tetra-O-acetyl-D-glucitol (70 mg) was added sodium methoxide (a 1 M methanol solution, 0.5 mL, 0.5 mmol), and the mixture was stirred for an hour at room temperature. To this reaction solution was added dry ice, and the solvent was evaporated under reduced pressure. Thus obtained residue was purified with silica gel column chromatography (chloroform:methanol=5:1) to obtain the title compound (35 mg, 31%, 3 steps) as a colorless oily compound. NMR data and MS data of the compound are shown in Table 1.

Provenance & Evidence