HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → 6-(4-Chloro-2-methyl-phenylamino)-7-fluoro-3H-benzoimidazole-5-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | HCID 178497005 | HCID 178497005 | — |
| Product | 6-(4-Chloro-2-methyl-phenylamino)-7-fluoro-3H-benzoimidazole-5-carboxylic acid methyl ester | HCID 58890718 | — |
Reaction Steps
7-Fluoro-6-o-tolylamino-3H-benzoimidazole-5-carboxylic acid methyl ester 7a is converted by the procedure already described for bromination, except N-chlorosuccinimide is used instead of N-bromosuccinimide, to yield the desired product. MS ESI (+) m/z 334, 336 (M+, Cl pattern) detected.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07973170B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-bed2f6b7e7974c2a984d3df5b41009ae |
| Source note | uspto-grants-2011_07 |