HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Tert-Butylaniline | HCID 69861 | — |
| Reactant | 4-Chloro-3-methoxy-2-methylpyridine | HCID 10583046 | — |
| Solvent | Phenol | HCID 996 | — |
| Product | 4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine | HCID 19693953 | — |
Reaction Steps
7.9 g of 4-chloro-3-methoxy-2-methylpyridine and 22.4 g of 4-tert-butylaniline are heated at 120° C. for 8 hours in 20 g of phenol. After cooling, the mixture is poured into NaOH and the product is extracted using methylene chloride. After concentrating, the excess of amine is distilled off in vacuo and the residue is crystallized using hexane. 9.5 g=55%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05723450 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-ed5d30e63cae482aa9ed8a44a63361f9 |
| Source note | uspto-grants-1998_03 |