反应详情

4-Chloro-6-cyano-7-(2-methoxyethoxy)quinoline (1.7 g) and 3-fluoro-4-nitrophenol (2.0 g) were suspended in chlorobenzene (20 ml), and the suspension was heated to reflux for 6 hours. After completion of the reaction, the solvent was distilled off, ethyl acetate was added, and a solid precipitated. The solid was filtered out and washed with ether, washed with 1N sodium hydroxide water and with water, and then dried to obtain 1.55 g of the title compound.

1. temperaturethe suspension was heated
2. temperatureto reflux for 6 hours
3. customAfter completion of the reaction
4. distillationthe solvent was distilled off
5. additionethyl acetate was added
6. customa solid precipitated
7. filtrationThe solid was filtered out
8. washwashed with ether
9. washwashed with 1N sodium hydroxide water and with water
10. customdried