反应详情

4-(4-Aminophenoxy)-7-(2-methoxyethoxy)-6-cyanoquinoline (109 mg, 0.325 mmol) was dissolved in toluene (5 ml) while heating, and then 4-fluorophenyl isocyanate (0.057 ml, 0.488 mmol) was added and the mixture was heated to reflux for 1 hour. After cooling, the precipitated crystals were filtered out, washed with ethyl acetate and dried under reduced pressure to obtain the title compound (148 mg, 0.311 mmol, 96.4%) as white crystals.

1. temperaturewhile heating
2. temperaturethe mixture was heated
3. temperatureto reflux for 1 hour
4. temperatureAfter cooling
5. filtrationthe precipitated crystals were filtered out
6. washwashed with ethyl acetate
7. customdried under reduced pressure