4-Fluorophenyl isocyanate → HCID 58930909, compound

HRID 1010160Notes

Reaction equation

HRID 1010160 reaction equation
[NH2:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][C:7]2[C:8]3[CH:15]=[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[NH:13][C:9]=3[N:10]=[CH:11][N:12]=2)=[CH:4][CH:3]=1.[F:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]=[C:31]=[O:32])=[CH:26][CH:25]=1>C1(C)C=CC=CC=1.C(#N)C>[CH2:19]([O:18][C:16]([C:14]1[NH:13][C:9]2[N:10]=[CH:11][N:12]=[C:7]([O:6][C:5]3[CH:21]=[CH:22][C:2]([NH:1][C:31]([NH:30][C:27]4[CH:28]=[CH:29][C:24]([F:23])=[CH:25][CH:26]=4)=[O:32])=[CH:3][CH:4]=3)[C:8]=2[CH:15]=1)=[O:17])[CH3:20]

Participants

5

Reactant 2

HCID 709554-Fluorophenyl isocyanateHCID 58931023HCID 58931023, compound

Product 1

HCID 58930909HCID 58930909, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6342AcetonitrileSolvent

Procedure

After dissolving 90 mg of ethyl 4-(4-aminophenoxy)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate in 3 ml of toluene and 1 ml of acetonitrile at 110° C., 16.6 μl of 4-fluorophenyl isocyanate was added and the mixture was stirred for 1 hour under reflux. After standing at room temperature, the precipitated crystals were filtered out and dried to obtain 110 mg of the title compound.

Workup

  1. temperatureunder reflux
  2. customAfter standing at room temperature
  3. filtrationthe precipitated crystals were filtered out
  4. customdried

Sources & evidence

ORD record
ord-c9ecef92c9c1405a84f700552e0c482b
Source dataset
uspto-grants-2011_07
Patent number
US07973160B2

Reaction notes

Loading…