HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dimethylformamide → 2-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]sulfanyl}-5-nitrothiophene
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dimethylformamide | HCID 6228 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 2-Bromo-5-nitrothiophene | HCID 83222 | — |
| Edukt | 7-(Benzyloxy)-6-methoxy-1,4-dihydro-4-quinolinethione | HCID 22936980 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | 2-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]sulfanyl}-5-nitrothiophene | HCID 58931211 | 76,9% |
Reaktionsschritte
7-(Benzyloxy)-6-methoxy-1,4-dihydro-4-quinolinethione (14.3 g), 2-bromo-5-nitrothiophene (10 g), potassium carbonate (9.9 g) and dimethylformamide (150 ml) were stirred together at room temperature for 6 hours. Water was added, and the precipitated solid was filtered out and washed with water and then ethyl acetate to obtain 15.7 g of a yellow powder.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07973160B2 |
| Quelldatensatz | uspto-grants-2011_07 |
| ORD ID | ord-1e27e9eba7884227976577ed999a2047 |
| Quellennotiz | uspto-grants-2011_07 |