Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 2-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]sulfanyl)-5-nitro-1,3-thiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromo-5-nitrothiazole | HCID 18211 | — |
| 반응물 | 7-(Benzyloxy)-6-methoxy-1,4-dihydro-4-quinolinethione | HCID 22936980 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]sulfanyl)-5-nitro-1,3-thiazole | HCID 58931052 | — |
반응 단계
7-(Benzyloxy)-6-methoxy-1,4-dihydro-4-quinolinethione (14.8 g), 2-bromo-5-nitro-1,3-thiazole (10.4 g), potassium carbonate (10.3 g) and dimethylformamide (150 ml) were stirred together at room temperature for 50 minutes. After adding 800 ml of water to the reaction solution, the precipitated solid was filtered out and washed with ethyl acetate to obtain 13.4 g of a light ochre powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07973160B2 |
| 출처 데이터셋 | uspto-grants-2011_07 |
| ORD ID | ord-84c71c8228ee4e3eb0a03cc5eabf62a6 |
| 출처 메모 | uspto-grants-2011_07 |