HRID1010257

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13648483

Phenyl cyclopropylcarbamate

C10H11NO2

结构：COc1cc2nccc(Oc3ccc(N)c(F)c3)c2cc1NC(=O)OCc1ccccc1

HCID58931409

未命名化合物

PRODUCTS

生成物

结构：COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(F)c3)c2cc1NC(=O)OCc1ccccc1

HCID58931295

未命名化合物

收率 9.2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

[4-(4-Amino-3-fluorophenoxy)-7-methoxyquinolin-6-yl]carbamic acid benzyl ester (100 mg) and cyclopropylcarbamic acid phenyl ester (64 mg) were heated and stirred in dimethylsulfoxide (0.7 ml) at 85° C. for 5 hours and 40 minutes, in the same manner as Example 224, to obtain the title compound (11 mg) as a solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-096462b4f38345d8b1bd0805c28fe5e9
来源数据集: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07973160B2
来源说明: uspto-grants-2011_07

反应 SMILES

[CH2:1]([O:8][C:9](=[O:32])[NH:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][C:20]=1[O:21][CH3:22])[N:17]=[CH:16][CH:15]=[C:14]2[O:23][C:24]1[CH:29]=[CH:28][C:27]([NH2:30])=[C:26]([F:31])[CH:25]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1([O:39][C:40](=O)[NH:41][CH:42]2[CH2:44][CH2:43]2)C=CC=CC=1>CS(C)=O>[CH2:1]([O:8][C:9](=[O:32])[NH:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][C:20]=1[O:21][CH3:22])[N:17]=[CH:16][CH:15]=[C:14]2[O:23][C:24]1[CH:29]=[CH:28][C:27]([NH:30][C:40]([NH:41][CH:42]2[CH2:44][CH2:43]2)=[O:39])=[C:26]([F:31])[CH:25]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1