2-Chloroethylamine hydrochloride → HCID 230241, compound

HRID 1010273Notes

Reaction equation

HRID 1010273 reaction equation
Cl.[Cl:2][CH2:3][CH2:4][NH2:5].[CH3:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].[C:12]([O:15]CC)(=[O:14])C>C(OCC)C.CCCCCC>[Cl:2][CH2:3][CH2:4][NH:5][C:12](=[O:14])[O:15][C:8]1[CH:7]=[CH:6][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 97937372-Chloroethylamine hydrochlorideHCID 21226206Ethyl acetate hexane

Product 1

HCID 230241HCID 230241, compoundYield 60.99%

Reagents, catalysts & solvents 1

HCID 21584099Diethylether hexaneSolvent

Procedure

2-Chloroethylamine hydrochloride (5.8 g, 50 mmol) was used for reaction in the same manner as Production Example 310-1, purification was performed by silica gel column chromatography (hexane/ethyl acetate system), the obtained crystals were suspended in diethyl ether/hexane, and the crystals were filtered out, washed with hexane and dried by aspiration to obtain the title compound (6.088 g, 30.49 mmol, 60.99%) as colorless crystals.

Workup

  1. filtrationthe crystals were filtered out
  2. washwashed with hexane
  3. customdried by aspiration

Sources & evidence

ORD record
ord-626616e940134d4cb3f3ad68e6121e12
Source dataset
uspto-grants-2011_07
Patent number
US07973160B2

Reaction notes

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