Pyridine → N-(6-(4-(3-Phenylureido)phenoxy)pyrimidin-4-yl)acetamide

Participants

Reaction Steps

N-(4-(6-Aminopyrimidin-4-yloxy)phenyl)-N′-phenylurea (60.0 mg, 0.187 mmol) was heated and stirred in an acetic anhydride (1 ml)—pyridine (1 ml) mixed solvent at 60° C. for 18 hours. After returning the reaction solution to room temperature, it was poured into water and the precipitated crystals were filtered out, washed with water and methanol and blow-dried to obtain the title compound (35.0 mg, 0.096 mmol, 52%) as colorless crystals.

Provenance & Evidence