Bicarbonate Ion → 2-[4-(3-Aminopyrrolidin-1-yl)-7-methylquinazolin-2-yl]phenol

HRID 101041Notes

Reaction equation

HRID 101041 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][CH:8]1[CH2:9][N:10]([c:13]2[n:14][c:15](-[c:24]3[c:25]([OH:30])[cH:26][cH:27][cH:28][cH:29]3)[n:16][c:17]3[cH:18][c:19]([CH3:23])[cH:20][cH:21][c:22]23)[CH2:11][CH2:12]1)([CH3:5])([CH3:6])[CH3:31].[Cl:37][CH2:38][Cl:39].[Na+:36].[O-:32][C:33]([OH:34])=[O:35]>>[NH2:7][CH:8]1[CH2:9][N:10]([c:13]2[n:14][c:15](-[c:24]3[c:25]([OH:30])[cH:26][cH:27][cH:28][cH:29]3)[n:16][c:17]3[cH:18][c:19]([CH3:23])[cH:20][cH:21][c:22]23)[CH2:11][CH2:12]1

Participants

5

Reactant 4

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 136121483tert-butyl N-[1-[2-(2-hydroxyphenyl)-7-methylquinazolin-4-yl]pyrrolidin-3-yl]carbamate

Product 1

HCID 1361215132-[4-(3-Aminopyrrolidin-1-yl)-7-methylquinazolin-2-yl]phenol

Sources & evidence

ORD record
ord-b09acaac6fee41ed9ca19e4452afaaa4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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