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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1010442Generated: October 31, 2026

Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate → 4-(4-(3-Ethylureido)-3-fluorophenoxy)-7-methoxyquinoline-6-carboxylic acid cis-(2-fluorocyclopropyl)amide

https://huagongshe.com/reaction/1010442

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 151348—
Reactant(1R,2S)-2-Fluorocyclopropan-1-amineHCID 10313105—
Reactant4-(4-(3-Ethylureido)-3-fluorophenoxy)-7-methoxyquinoline-6-carboxylic acidHCID 22936395—
SolventTriethylamineHCID 8471—
Product4-(4-(3-Ethylureido)-3-fluorophenoxy)-7-methoxyquinoline-6-carboxylic acid cis-(2-fluorocyclopropyl)amideHCID 67203132—

Reaction Steps

4-(4-(3-Ethylureido)-3-fluorophenoxy)-7-methoxyquinoline-6-carboxylic acid (20 mg) was treated with cis-2-fluorocyclopropylamine, triethylamine and benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate in the same manner as Example 634, to obtain the title compound (9 mg) as a solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07973160B2
Source datasetuspto-grants-2011_07
ORD IDord-3c86e3aeb2614278ab4c0acd2ac5ddca
Source noteuspto-grants-2011_07