m-Chloroperbenzoic acid → HCID 59707967, compound

Participants

Reaction Steps

16.1 g of N-2-((2-methoxyethoxy)methoxy)ethylmorpholine was dissolved in 85 g of dichloromethane, which was ice cooled. To the solution, 24.9 g of 65% pure m-chloroperbenzoic acid in 250 g of dichloromethane was added dropwise at such a rate that the mixture might not exceed 5° C. The mixture was allowed to mature for one hour at room temperature. The reaction solution was concentrated below 30° C., and the residue was purified by column chromatography (basic alumina, elute: dichloromethane/methanol). The eluate was concentrated whereupon the desired compound solidified. The amount was 15.5 g.

Provenance & Evidence