Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pinacolone | HCID 6416 | — |
| Reactant | 4-Methylbenzaldehyde | HCID 7725 | — |
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 11514521 | HCID 11514521 | — |
Reaction Steps
A solution of 5.13 g of ammonium acetate, 886 μl of cyanoacetic acid ethyl ester, 1.03 ml of 3,3-dimethyl-2-butanone and 1 g of 4-methylbenzaldehyde in 40 ml of ethanol is stirred for 6 hours at 80° C. Then, it is stirred for 5 more hours at 20° C. The precipitated product is filtered off. The filtrate is rewashed with ethanol and hexane. 630 mg of product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07977325B2 |
|---|
| Source dataset | uspto-grants-2011_07 |
|---|
| ORD ID | ord-522582697085438a9929c0f3da70f20f |
|---|
| Source note | uspto-grants-2011_07 |
|---|
