Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | 3,5-Dimethoxybenzaldehyde | HCID 81747 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 11393839 | HCID 11393839 | — |
Reaction Steps
4.2 ml of ethylene glycol, 4.1 ml of trimethyl orthoformate and 5 mg of p-toluenesulfonic acid are added to a solution of 5 g of 3,5 dimethoxy benzaldehyde in 100 ml of dichloromethane. It is allowed to stir for 20 more hours at 25° C. Then, it is washed with saturated sodium bicarbonate solution and saturated sodium chloride solution, dried on sodium sulfate, and concentrated by evaporation in a vacuum. The crude product is purified by column chromatography. 5.67 g of product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07977325B2 |
|---|
| Source dataset | uspto-grants-2011_07 |
|---|
| ORD ID | ord-16f04728e4554d1db2e5075e8e6be5ad |
|---|
| Source note | uspto-grants-2011_07 |
|---|
