HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → 2-[(6-Chloro-pyridin-3-ylmethyl)-amino]-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Reactant | 6-Chloropyridine-3-carbaldehyde | HCID 2764053 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[(6-Chloro-pyridin-3-ylmethyl)-amino]-ethanol | HCID 15390297 | — |
Reaction Steps
This compound was made in a manner analogous to that set forth in Step A of Example 2, using 8.5 grams (0.060 mole) of (6-chloro-3-pyridyl)formaldehyde (known compound), 4.4 grams (0.072 mole) of 2-aminoethan-1-ol, 4.9 grams (0.048 mole) of triethylamine, 14.4 grams (0.119 mole) of magnesium sulfate, and 13.6 grams (0.360 mole) of sodium borohydride in 150 mL of methanol. The yield of the subject compound was about 11.3 grams, which included an impurity of about 10% by weight. The NMR spectrum was consistent with the proposed structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977332B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-5437cc5e13f649c1bec244f215daaa03 |
| Source note | uspto-grants-2011_07 |