HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (2-Aminoethyl)[(2-chloro(1,3-thiazol-5-yl))methyl][(4-methoxyphenyl)methyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (tert-butoxy)-N-(2-{[(2-chloro(1,3-thiazol-5-yl))methyl][(4-methoxyphenyl)methyl]amino}ethyl)carboxamide | HCID 131728996 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2-Aminoethyl)[(2-chloro(1,3-thiazol-5-yl))methyl][(4-methoxyphenyl)methyl]amine | HCID 67267223 | — |
Reaction Steps
This compound was made in a manner analogous to that set forth in Step C of Example 1, using 0.3 gram (0.0007 mole) of (tert-butoxy)-N-(2-{[(2-chloro(1,3-thiazol-5-yl))methyl][(4-methoxyphenyl)methyl]amino}ethyl)carboxamide and 3 mL (excess) of trifluoroacetic acid in 20 mL of methylene chloride. The yield of subject compound was 0.20 gram. The NMR spectrum was consistent with the proposed structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977332B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-b15650cd233d409192b9cd98ecb2bfd6 |
| Source note | uspto-grants-2011_07 |