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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1010544Generated: October 27, 2026

Trifluoroacetic acid → (2-Aminoethyl)[(2-chloro(1,3-thiazol-5-yl))methyl][(4-methoxyphenyl)methyl]amine

https://huagongshe.com/reaction/1010544

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant(tert-butoxy)-N-(2-{[(2-chloro(1,3-thiazol-5-yl))methyl][(4-methoxyphenyl)methyl]amino}ethyl)carboxamideHCID 131728996—
SolventDichloromethaneHCID 6344—
Product(2-Aminoethyl)[(2-chloro(1,3-thiazol-5-yl))methyl][(4-methoxyphenyl)methyl]amineHCID 67267223—

Reaction Steps

This compound was made in a manner analogous to that set forth in Step C of Example 1, using 0.3 gram (0.0007 mole) of (tert-butoxy)-N-(2-{[(2-chloro(1,3-thiazol-5-yl))methyl][(4-methoxyphenyl)methyl]amino}ethyl)carboxamide and 3 mL (excess) of trifluoroacetic acid in 20 mL of methylene chloride. The yield of subject compound was 0.20 gram. The NMR spectrum was consistent with the proposed structure.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07977332B2
Source datasetuspto-grants-2011_07
ORD IDord-b15650cd233d409192b9cd98ecb2bfd6
Source noteuspto-grants-2011_07