Sodium Hydroxide → HCID 59808430, compound

Participants

Reaction Steps

1.0 g (4.00 mmol) 3-[4-(4-methoxy-phenyl)-imidazol-1-yl]-1,1-dimethyl-propylamine and 4.00 g pyridine hydrochloride were stirred for 2 h at 200° C. in a sealed reaction vessel in a microwave. The reaction mixture was poured into 40 mL ice water and 40 mL ethyl acetate, the pH of the aqueous phase was adjusted to over 9 with sodium hydroxide solution (2M) and the phases were separated. The aqueous phase was extracted five times with 50 mL ethyl acetate. The combined organic phases were dried over magnesium sulphate and the solvent was eliminated using the rotary evaporator. 0.530 g (2.16 mmol, 54%) 3-[4-(4-hydroxy-phenyl)-imidazol-1-yl]-1,1-dimethyl-propylamine were obtained as a colourless solid.

Provenance & Evidence