HCID 11642463, compound → HCID 11649294, compound

Participants

Reaction Steps

1.69 g (3.07 mmol) N-[3-(2-{3-[4-(4-nitro-phenyl)-imidazol-1-yl]-1,1-dimethyl-propylamino}-1-hydroxyethyl)-phenyl]-benzenesulphonamide, 0.10 g palladium on activated charcoal, and 30 mL methanol were shaken in an autoclave at ambient temperature under a hydrogen atmosphere of 1 bar for 3 h. The reaction mixture was filtered and the filtrate was freed from solvent using the rotary evaporator. 1.59 g (3.05 mmol, 99%) N-[3-(2-{3-[4-(4-amino-phenyl)-imidazol-1-yl]-1,1-dimethyl-propylamino}-1-hydroxyethyl)-phenyl]-benzenesulphonamide were obtained as a colourless solid.

Provenance & Evidence