HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 67313854, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | HCID 12709317 | HCID 12709317 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 67313854 | HCID 67313854 | 100.1% |
Reaction Steps
12.2 Under an argon atmosphere, 120 ml of DMF are added to 28.01 g of 1-tert-butyloxycarbonyl-(2R,4S)-4-hydroxyproline ethyl ester, 30.28 g of tert-butyldimethylchlorosilane and 16.41 g of imidazole. The mixture is stirred for a further 2 hours. MTB ether is added, and the mixture is subjected to conventional work-up. The residue is chromatographed on silica gel, giving 40.4 g of 1-tert-butyloxycarbonyl-(2R,4S)-4-(tert-butyldimethylsilyl-oxy)proline ethyl ester as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977343B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-6ea549ff5af941d8bed45f8a7bbb627c |
| Source note | uspto-grants-2011_07 |