2-Chlorophenol → HCID 67315305, compound

Participants

Reaction Steps

12.5 Reaction of 1.5 g of 1-tert-butyloxycarbonyl-(2R,4S)-2-(methylsulfonyloxymethyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine with 560 μl of 2-chlorophenol and 1.19 g of caesium carbonate in 15 ml of DMF under standard conditions gives 751 mg of (2R,4S)-1-tert-butyloxycarbonyl-2-(2-chlorophenoxymethyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine. 223 mg of the silyl-eliminated product (2R,4S)-1-tert-butyloxycarbonyl-2-(2-chlorophenoxymethyl)-4-hydroxypyrrolidine are formed as by-product.

Provenance & Evidence