3-(Trifluoromethyl)aniline → HCID 11852874, compound

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Reaction Steps

0.15 ml of DIEA are added dropwise to a cold (0° C.) mixture of 55 mg of crude (4-imidazo[4,5-c]pyridin-1-yl-phenyl)-acetic acid, 39 mg of 3-aminobenzotrifluoride and 77 mg of TBTU in 0.5 ml of DMF. The mixture obtained is allowed to warm to rt, stirred for 2 hours, diluted with EtOAc and washed with a saturated aqueous solution of NaHCO3, H2O, and brine. The organic phase obtained is dried (Na2SO4), filtered and concentrated in vacuo. The evaporation residue obtained is purified by silica gel column chromatography. 2-(4-Imidazo[4,5-c]pyridin-1-yl-phenyl)-N-(3-trifluoromethyl-phenyl]-acetamide is obtained in the form of a solid: ES-MS: 397.0 [M+H]+; single peak at tR=3.52 min (System 1); Rf=0.18 (CH2Cl2/MeOH, 94:6).

Provenance & Evidence