Sodium Carbonate → HCID 59864214, compound

Participants

Reaction Steps

A mixture of 500 mg of 5-amino-2-bromobenzotrifluoride (Dakwood Products, Inc.), 6.2 mMol 3-bromophenylboronic acid (Aldrich), 70 mg of Pd(PPh3)4 and 5 ml of Na2CO3, 2 M solution in H2O, in 14 ml of toluene is stirred at reflux for 1 our. The mixture obtained is allowed to cool to rt and filtered through a pad of celite. The layers obtained are separated and the aqueous phase obtained is extracted with CH2Cl2. The organic phase obtained is washed with brine, dried (Na2SO4), filtered and concentrated in vacuo. The concentration residue obtained is subjected to MPLC(CH3CN/H2O/TFA). 3′-Bromo-2-trifluoromethyl-biphenyl-4-amine is obtained. MS: 315.9 [M−1]−; HPLCDtRet=4.9; Rf=0.16 (Hexane/EtOAc, 4:1).

Provenance & Evidence