HCID 67021573, compound → HCID 67021316, compound

HRID 1010720Notes

Reaction equation

HRID 1010720 reaction equation
[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N+:18]([O-])=O)=[CH:7][CH:6]=1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1[CH:6]=[CH:7][C:8]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[NH2:18])=[CH:9][CH:10]=1

Participants

4

Reactant 1

HCID 67021573HCID 67021573, compound

Product 1

HCID 67021316HCID 67021316, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.700 g of a suspension of [4-(2-nitro-phenylamino)-phenyl]-acetic acid methyl ester and 0.240 g of Pd/C (10%) in 20 ml of MeOH is stirred for 3 hours at rt under a hydrogen atmosphere. The mixture obtained is filtered through a pad of Celite and the filtrate obtained is concentrated. [4-(2-Amino-phenylamino)-phenyl]-acetic acid methyl ester is obtained in the form of an oil: ES-MS: 257.1 [M+H]+; single peak at tR=3.04 min (System 1).

Workup

  1. customThe mixture obtained
  2. filtrationis filtered through a pad of Celite
  3. customthe filtrate obtained
  4. concentrationis concentrated

Sources & evidence

ORD record
ord-448bf6eccb3c451fbb66376f45901496
Source dataset
uspto-grants-2011_07
Patent number
US07977338B2

Reaction notes

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