4-Aminophenylacetic acid → HCID 67021624, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.5 ml of 2-nitrofluorobenzene (Aldrich), 1.44 g of 4-aminophenyl acetic acid and 0.550 g of KF is stirred at 170° C. for 16 hours in a sealed tube. The mixture obtained is allowed to cool to rt, triturated in CH2Cl2/MeOH (95:5) and filtered. The filtrate obtained is concentrated and the concentrate obtained is purified by silica gel column chromatography. [4-(2-Nitro-phenylamino)-phenyl]-acetic acid is obtained in the form of a solid: ES-MS: 273.0 [M+H]+; single peak at tR=4.44 min (System 1); Rf=0.20 (CH2Cl2/MeOH, 95:5).

Provenance & Evidence