Ethanol → [4-(3-Amino-pyridin-2-ylamino)-2-chloro-phenyl]-acetic acid ethyl ester

Participants

Reaction Steps

is obtained analogously to the method as described in Step 1.3 but using [2-chloro-4-(3-nitro-pyridin-2-ylamino)-phenyl]-acetic acid ethyl ester instead of [4-(3-nitro-pyridin-2-ylamino)-phenyl]-acetic acid methyl ester as a starting material, EtOH instead of MeOH as the solvent and the reaction mixture is stirred for 22 hours instead of 4 hours at rt. ES-MS: 306.1 [M+H]+; single peak at tR=3.06 min (System 1); Rf=0.16 (Hexane/EtOAc, 1:1).

Provenance & Evidence