Imatinib → Imatinib Mesylate

Participants

Reaction Steps

Imatinib base (1 g) was dissolved in nitromethane (20 ml) at 90° C. and methanesulfonic acid (0.125 ml) was added. The solution thus formed was allowed to crystallise at 10° C. for 5 h. The white solid was filtered, washed with t-butyl methyl ether, and the solid matter was dried in a stream of nitrogen for 4 h to obtain imatinib mesylate Form VII (1.1 g, yield: 93%).

Provenance & Evidence