Water → Imatinib Mesylate

Participants

Reaction Steps

Imatinib base (4 g) was suspended in isopropanol (80 ml) and water (11 ml) at −10° C. Methanesulfonic acid (0.5 ml in 4 ml of isopropanol) was added with stirring and the suspension was stirred for additional 20 min at −5° C. obtaining thus the solution of imatinib mesylate. Then the solution was allowed to crystallize without stirring at −20° C. overnight. The white solid was filtered at −10° C., washed with isopropanol (10 ml) and dried in a stream of nitrogen for 1 h to obtain imatinib mesylate Form XIV (3 g).

Provenance & Evidence