HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1010821Generated: October 28, 2026
Cyanoacetamide → 2-Aminothiophene-3-carboxamide
https://huagongshe.com/reaction/1010821
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,4-Dithiane-2,5-diol | HCID 98330 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Aminothiophene-3-carboxamide | HCID 699495 | 64% |
Reaction Steps
1,4-dithian-2,5-diol (4.56 g, 30 mmole) and 2-cyanoacetamide (2.52 g, 30 mmole) were combined in ethanol (50 ml). Triethylamine (6 ml) was added and heated to 70° C. for 1 hour. The volume of solvent was reduced under vacuum, and the product was isolated by filtration. Product was recrystallized from ethanol to give 2.71 g of product (yield 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07977342B2 |
|---|
| Source dataset | uspto-grants-2011_07 |
|---|
| ORD ID | ord-d29932dd8477499eafd8b0fdde1194eb |
|---|
| Source note | uspto-grants-2011_07 |
|---|
