Hydrochloric Acid → HCID 136008001, compound

Participants

Reaction Steps

N-(2-Butyl-4-cyano-5-methyl-2H-pyrazol-3-yl)-2-fluoro-benzamide (4.0 g, 13.3 mmole) was suspended in 26 ml 1M sodium hydroxide, and 30% hydrogen peroxide (10 ml) and ethanol (5 ml) were added. The reaction mixture was heated to reflux for 4 hours, then more 30% hydrogen peroxide (10 ml) was added and heated to reflux overnight. The reaction mixture was cooled and acidified with diluted hydrochloric acid to pH 6.0. The product was collected by filtration and dried under vacuum to obtain 1.29 g of product (yield: 32%).

Provenance & Evidence