Tert-Butylamine → HCID 86761351, compound

Participants

Reaction Conditions

Reaction Steps

4.4 g of the compound [5-4] was dissolved in 40 mL of ethanol, 20 mL of tert-butylamine was added thereto, and the mixture was stirred for 3 days at 50° C. The reaction solution was concentrated, and the resulting residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=100/0-0/100), to obtain 3.1 g of tert-butyl ((1S)-1-{4-[(1S)-2-(tert-butylamino)-1-hydroxyethyl]phenyl}ethyl)carbamate [5-5] (hereinafter, referred to as the compound [5-5]) as a white solid.

Provenance & Evidence