2-Butanamine, 2-methyl- → HCID 131729004, compound

Participants

Reaction Conditions

Reaction Steps

30 mg of the compound [7-2] was dissolved in 2 mL of ethanol, then 2 mL of tert-amylamine was added thereto, and the mixture was stirred overnight at 50° C. The reaction solution was concentrated, and then the resulting residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=100/0-20/80), to obtain 31 mg of tert-butyl[(1S)-1-(4-{2-[(1,1-dimethylpropyl) amino]-1-hydroxyethyl}phenyl)ethyl]carbamate [7-3] (hereinafter, referred to as the compound [7-3]) as a colorless oily product.

Provenance & Evidence