Trifluoroacetic acid → HCID 67313356, compound

Participants

Reaction Steps

78 mg of the compound [6-1] was dissolved in 2 mL of chloroform, then 2 mL of trifluoroacetic acid was added thereto, and the mixture was stirred for 1 hour at room temperature. The reaction mixture was concentrated under reduced pressure, dissolved in methanol, and passed through a weak ion exchange resin to remove the trifluoroacetic acid. The solvent was distilled off to obtain 55 mg of (1R)-1-{4-[(1S)-1-aminoethyl]phenyl}-2-(tert-butylamino)ethanol [11-3] as a white solid. The compound [11-3] (hereinafter, referred to as the compound [11-3]) was used in the subsequent reaction without further purification.

Provenance & Evidence