HCID 67313255, compound → HCID 67314727, compound

Participants

Reaction Steps

21 mg of the compound [17-1] was dissolved in a mixed solvent of 3 mL of tetrahydrofuran and 3 mL of methanol, then 20 mg of a carbon catalyst of 20% palladium hydroxide was added thereto, and the mixture was stirred for 2 hours at room temperature under hydrogen atmosphere. The catalyst was filtered through celite, and the filtrate was concentrated under reduced pressure. Diethylether was added to the resulting residue, and thus produced solid was taken by filtration to obtain 6 mg of 2-({(1S)-1-[4-(1-hydroxy-2-piperidin-4-ylethyl)phenyl]ethyl}amino)-4-(8-methylimidazo[1,2-a]pyridin-3-yl)pyrimidine-5-carbonitrile [17-2] (hereinafter, referred to as the compound [17-2]).

Provenance & Evidence