HCID 67314324, compound → HCID 67313969, compound

Participants

Reaction Steps

118 mg of the compound [25-2] was dissolved in 4 mL of ethanol, then 50 mg of a carbon catalyst of 20% palladium hydroxide was added thereto, and the mixture was stirred overnight at room temperature under hydrogen atmosphere. The catalyst was filtered through celite, the filtrate was concentrated under reduced pressure, and then the resulting residue was purified by preparative thin-layer chromatography, to obtain 66 mg of 4-(8-ethylimidazo[1,2-a]pyridin-3-yl)-2-[((1S)-1-{4-[hydroxy(piperidin-4-yl)methyl]phenyl}ethyl)amino]pyrimidine-5-carbonitrile [25-3] (hereinafter, referred to as the compound [25-3]).

Provenance & Evidence