HCID 131729009, compound → HCID 86761354, compound

HRID 1010905Notes

Reaction equation

HRID 1010905 reaction equation
[C:1]([O:5][C:6](=[O:27])[NH:7][C@H:8]([C:10]1[CH:15]=[CH:14][C:13]([CH:16]([OH:26])[CH:17]2[CH2:22][CH2:21][N:20](C(C)C)[CH2:19][CH2:18]2)=[CH:12][CH:11]=1)[CH3:9])([CH3:4])([CH3:3])[CH3:2]>CC(C)=O>[C:1]([O:5][C:6](=[O:27])[NH:7][C@H:8]([C:10]1[CH:15]=[CH:14][C:13]([CH:16]([OH:26])[CH:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)=[CH:12][CH:11]=1)[CH3:9])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 1

HCID 131729009HCID 131729009, compound2×

Product 1

HCID 86761354HCID 86761354, compoundYield 121%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2.14 g of tert-butyl((1S)-1-{4-[hydroxy(1-isopropylpiperidin-4-yl) methyl]phenyl}ethyl)carbamate [334] (hereinafter, referred to as the compound [334]) was obtained from 2.3 g of the compound [33-3] and 15 mL of acetone according to the method of Example 1 7-(3).

Sources & evidence

ORD record
ord-fe6c5cb6c81e4cdaaf29144000e5c9e2
Source dataset
uspto-grants-2011_07
Patent number
US07977336B2

Reaction notes

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