Sodium Hydroxide → HCID 67314192, compound

Participants

Reaction Conditions

Reaction Steps

237 mg of the compound [37-3] was dissolved in a mixed solvent of 3 mL of tetrahydrofuran and 1 mL of methanol, then 163 μL of 5N aqueous solution of sodium hydroxide was added thereto, and the mixture was stirred for 5 hours at 50° C. After standing to cool, the reaction solution was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent: chloroform/methanol=95/5-93/7), to obtain 156 mg of 4-(8-chloroimidazo[1,2-a]pyridin-3-yl)-2-[((1S)-1-{4-[hydroxy(piperidin-4-yl)methyl]phenyl}ethyl)amino]pyrimidine-5-carbonitrile [374] (hereinafter, referred to as the compound [374]).

Provenance & Evidence