3,4-dihydro-2H-pyran → 2,6-Dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

Participants

Role	Name	HCID	Charge
Reactant	3,4-dihydro-2H-pyran	HCID 8080	—
Reactant	2,6-Dichloropurine	HCID 5324412	—
Catalyst	p-Toluenesulfonic acid	HCID 6101	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	2,6-Dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine	HCID 270265	102.1%

Reaction Conditions

Temperature	50 °C

Reaction Steps

To 2,6-dichloropurine (25.0 g) was added ethyl acetate (260 mL), followed by p-toluenesulfonic acid (0.253 g). The mixture was heated to 50° C. and then 3,4-dihydro-2H-pyran (16.8 g) was added. The reaction mixture was then heated at 50° C. for 4 hours. The reaction mixture was evaporated in vacuo to give the title compound as a yellow solid (36.9 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07977344B2
Source dataset	uspto-grants-2011_07
ORD ID	ord-cec08e628ba14815a8732d37fca44864
Source note	uspto-grants-2011_07