Potassium Carbonate → HCID 57699757, compound

Participants

Reaction Steps

To a solution of 8-methoxy-N2-pentyl-9H-purine-2,6-diamine trifluoroacetic acid salt (223 mg) in dry DMF (3.85 mL) was added potassium carbonate (339 mg) at 60° C. and the mixture was stirred for 90 mins. The mixture was cooled to room temperature and 4-(bromomethyl)tetrahydro-2H-pyran (121 mg) was added in one portion. The reaction was stirred at 50° C. overnight and was then cooled and taken up in EtOAc (20 mL). The organics were washed with water (2×10 mL), separated, dried over MgSO4, filtered and concentrated in vacuo to give an off-white solid. The crude material was purified by C18 reverse phase chromatography (ISCO) using water (0.1% formic acid)-acetonitrile (0.05% formic acid) as eluent (20-60%) to afford the title compound as an off-white solid (140 mg).

Provenance & Evidence