Dichloromethane → HCID 57699761, compound

Participants

Reaction Steps

A solution of 2-[(2-methylbutyl)oxy]-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (245 mg) in dry chloroform (2.9 mL) was cooled to 0° C. and NBS (150 mg) was added to give a green/brown solution. The reaction mixture was stirred at room temperature for 6 h. The mixture was taken up into DCM (20 mL) and was washed with water (20 mL). The organics were separated, dried by passing through a hydrophobic frit and concentrated in vacuo to give the title compound as green solid (292 mg).

Provenance & Evidence