反应详情

温度

60 °C

To a solution of 2-chloro-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine (1.30 g) in dry chloroform (32 mL) at room temperature was added NBS (2.16 g). The reaction was stirred at 60° C. for 6 h. the mixture was cooled, taken up in DCM (50 mL) and washed with water (50 mL). The organics were passed through a hydrophobic frit and concentrated in vacuo to give the title compound as a brown solid (1.36 g).

1. temperaturewas cooled
2. washwashed with water (50 mL)
3. concentrationconcentrated in vacuo