反应详情

温度

1 °C

2-[(2-Cyclopropylethyl)oxy]-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (1.579 g) was dissolved in chloroform (15 mL) and was cooled in an ice bath to 1° C. NBS (1.02 g) was added gradually, keeping the reaction temperature below 2° C. The reaction was stirred for 30 mins (with cooling in an ice bath) before being allowed to warm to room temperature. The reaction was then stirred for 6 h. Chloroform (50 mL) was added and the mixture was partitioned with water (50 mL) and was separated using a hydrophobic frit. The organics were evaporated under reduced pressure to give the title compound as a brown foam (1.867 g).

1. customthe reaction temperature below 2° C
2. temperature(with cooling in an ice bath)
3. temperatureto warm to room temperature
4. stirringThe reaction was then stirred for 6 h
5. customthe mixture was partitioned with water (50 mL)
6. customwas separated
7. customThe organics were evaporated under reduced pressure