反应详情

A solution of 2,2-dimethyltetrahydro-2H-pyran-4-carbaldehyde (2.5 g) in ethanol (30 mL) was cooled (ice bath) and sodium borohydride (665 mg) was added with stirring. The ice bath was removed and the mixture was allowed to warm to room temperature. After 2 h the reaction was heated to 50° C. for 1 h, then allowed to cool to room temperature. The solvent was evaporated and the residue was treated with brine, acidified and extracted into DCM (×3). The combined organics were dried through a hydrophobic frit and evaporated to give a clear oil (2.54 g).

1. additionwas added
2. customThe ice bath was removed
3. temperatureAfter 2 h the reaction was heated to 50° C. for 1 h
4. temperatureto cool to room temperature
5. customThe solvent was evaporated
6. additionthe residue was treated with brine
7. extractionextracted into DCM (×3)
8. customThe combined organics were dried through a hydrophobic frit
9. customevaporated